Introduction The use of testosterone in women for hypoactive sexual desire disorder (HSDD) remains an area that generates controversy and debate despite a growing wealth of literature and increasing use in clinical practice. Perhaps one of the main reasons is that many healthcare professionals, as well as the general public, still do not perceive testosterone… Read More
Long term risks of premature or early surgical menopause: a focus on cognition
Summary A recent publication by Rocca and co-workers [1], with accompanying commentary [2], expands this group’s previous work [3] investigating the impact of bilateral oophorectomy (BO) on neurocognitive outcomes in women. The aim of the current study was to investigate the risk of mild cognitive impairment in premenopausal women who underwent BO. This study involved… Read More
Vaginal laser is no better than placebo
Summary A recently published randomised controlled trial has cast doubt on the efficacy of vaginal laser for the alleviation of vaginal symptoms associated with the menopause [1]. This study was a sham controlled, double blind randomised trial of the fractioned CO2 laser over 12 months. Participants had to be clearly postmenopausal with at least one… Read More
Metabolic syndrome and breast cancer in postmenopausal women
Summary Recently, Palmiero et al. [1] reported the results of a study aimed at assessing the prevalence of the metabolic syndrome (MetS), diagnosed according to current guidelines, in postmenopausal women with breast cancer, and determine its role as an independent risk factor. For this, 755 postmenopausal women (48 to 67 years) referred for cardiac evaluation… Read More
Age at menopause and the risk of lung cancer: a systematic review and meta-analysis
Summary Chung et al. [1] have recently published a systematic review and meta-analysis aimed at determining the association of early and late menopause onset with the risk of developing lung cancer. The authors reviewed and obtained through PubMed, EMBASE and Scopus database search studies analyzing this possible association. A total of twenty-eight studies were included… Read More
Is there a potential dual effect of denosumab for the treatment of osteoporosis and sarcopenia?
Summary El Miedany et al. [1] recently published data of a study aimed at assessing if denosumab has a unique dual effect on both, bone and muscle, in comparison to other anti-resorptive agents and also its effectiveness during the follow-up period after completing treatment when compared to other anti-resorptive agents. For this, the authors looked… Read More
Vaginal changes in collagen after carbon dioxide laser application in postmenopausal women with the genitourinary syndrome: A pilot study.
Summary Bretas et al. [1] have recently published data of fourteen sexually active postmenopausal women with vulvovaginal atrophy, aged 45 to 65 with aim of evaluating the clinical response and collagen remodeling in the vaginal wall after three monthly sessions of carbon dioxide (CO2) laser application. Women filled out clinical questionnaires (Vaginal Health Index [VHI],… Read More
Postmenopausal hormone therapy protects kidneys
Summary Recently, a group of Korean internists published a paper in the journal Scientific Reports describing the results of their analysis of the national health insurance database focusing on the effects of menopausal hormone therapy (MHT) on the incidence of end-stage renal disease (ESRD)[1]. As a total, 4,905 Korean postmenopausal women developed ESRD, among the… Read More
Association of oral contraceptives and tubal ligation with risk of early natural menopause
Summary Langton et al. [1] have examined the association of oral contraceptive (OC) use and tubal ligation (TL) with natural menopause before the age of 45 years in a population-based study within the prospective Nurses’ Health Study II (NHSII) cohort. Participants were followed from 1989 to 2017 and response rates were 85-90% for each cycle.… Read More
Is transdermal estradiol safer then oral estrogen in terms of VTE risk?
Summary Blondon and colleagues [1] have recently reported their observational findings for the comparison of venous thromboembolic events (VTE) in users of oral conjugated equine estrogens (CEE), oral estradiol (E2) and transdermal E2 (TE2). They employed a retrospective cohort design using data from the Department of Veteran Affairs. Veterans, aged 40 to 89 years, who… Read More